What happens if you drink a glass or two of alcohol after taking an antibiotic tablet?When can you drink alcohol, how many hours or days after antibiotics can you drink alcohol so as not to harm your health?
Antibiotic and alcohol
A mandatory consequence of the use of alcohol and antibiotics is the reduction of the effectiveness of the treatment.When drinking alcoholic beverages, inflammatory processes develop in the intestines and local immunity decreases.
At the same time, the antibiotic disorder in the intestine, which is provoked by taking the antibiotic, increases.
Violation of drug concentration
The antibiotic begins to work after it reaches a sufficiently high therapeutic concentration in the blood.Due to the consumption of alcoholic beverages, the amount of the drug in the body decreases.
This type of medication, when trying to take antibiotics after alcohol, can be considered pointless and even dangerous.
Violation of the treatment regimen, reducing the concentration of the drug, increases the resistance of the pathogenic microflora to the action of the antibiotic.And the disease itself, against which an antibiotic is prescribed, has a chance to go from acute to chronic.
The concentration of the drug decreases due to the fact that the nephrotoxic metabolite of ethyl alcohol, acetaldehyde, disrupts the process of reabsorption of nutrients in the renal tubules.
Water reabsorption is also impaired, which increases blood viscosity, and the concentration of the antibiotic in the blood can change in the most unpredictable way.
Characteristics of metabolism
Antibiotics are drugs that are metabolized in the liver.Busy with the processing of ethyl alcohol, the liver does not have time to neutralize all possible intermediate metabolic products of the drug.
In addition, ethanol can affect the activity of liver enzymes and even react directly with the antibiotic or its metabolites.These properties are expressed differently in antibacterial drugs.
One of the most dangerous features of combining a drug with ethyl alcohol is the interaction of these chemical compounds with the development of a disulfiram-like reaction.
Let's find out if it is possible to drink alcohol, beer while taking antibiotics, then it is not dangerous to drink alcohol, and then it is absolutely prohibited.
Disulfiram-like reaction
The disulfiram reaction is used to code for alcoholism, accompanied by nausea, cramps, cough, vomiting, shortness of breath, and a drop in blood pressure.
A similar effect occurs quite often when taking drugs with ethanol.
Below is a list of which antibiotics after taking and for how long you should not drink alcohol.
The consequences of ethanol intake during antibiotic treatment are dose-dependent.
When you can drink alcohol after taking tablets or antibiotic injections is calculated based on the time it takes for the antibiotic to be eliminated from the body.
List of antibiotics
Do not drink with alcohol:
- nitroimidazoles - do not combine with alcohol for up to 48 hours (the drugs give a reaction similar to disulfiram);
- cephalosporins - the chemical structure of this group resembles the structure of the disulfiram molecule, which gives a disulfiram-like reaction with ethyl alcohol.You can drink alcohol every other day;in case of renal insufficiency, the interval is prolonged;
- fluoroquinolones - synthetic antibiotics depress the nervous system and can cause coma.Take alcohol no earlier than 1.5 days;
- tetracyclines - high risk of damage to liver hepatocytes;they are eliminated from the body for a long time.You can drink alcohol after 3 days;
- aminoglycosides are ototoxic, nephrotoxic, drug side effects increase, and drug toxicity increases.Drink alcohol no earlier than 0.5 months;
- lincosamides - affect the central nervous system and the liver, a reaction to disulfiram develops.You can drink alcohol 4 days after the treatment;
- macrolides - the risk of liver cirrhosis increases, especially when taking erythromycin, they are slowly eliminated from the body.Alcohol is allowed after 3.5 days;
- anti-tuberculosis drugs - can cause drug-induced hepatitis with a fulminant course.Alcoholic beverages are prohibited!
The rate of elimination of antibacterial drugs from different environments of the body is different.So, if aminoglycosides are eliminated from the blood of adults in an average of 2.5 hours, then from the fluid of the inner ear this time can be up to 350 hours.
If we consider the ototoxicity of aminoglycosides, it is easy to understand that drinking alcohol within 2 weeks after treatment can cause deafness.
Interaction
A disulfiram-like reaction during antibiotic treatment and alcohol consumption develops due to blocking the synthesis of enzymes that break down the ethanol molecule into simple substances.
The consequence is an increase in the concentration in the blood of the intermediate product of the breakdown of ethyl alcohol - acetaldehyde.The ethanol metabolite acetaldehyde is more toxic than ethyl alcohol itself.
And the lack of liver enzymes as a result of a toxic effect on the liver leads to a decrease in the synthesis of norepinephrine, which is why the symptoms of intoxication the next morning are brighter and more difficult to tolerate.
Consequences
The combination of small doses of alcohol and medicine may not cause any symptoms, but drinking large doses of alcohol increases the side effects of both the medicine and the ethyl alcohol.
One of the most dangerous consequences of combining alcohol with an antibiotic is a disulfiram-like reaction.The danger of this condition is that it is masked by alcohol intoxication and is not recognized by others as a distress signal.
The reaction to disulfiram is caused by an increase in the concentration of acetaldehyde in the blood and is manifested by the following symptoms:
- palpitations;
- nausea, vomiting;
- hot flush, feeling of heat;
- vertigo;
- abdominal pain;
- sudden drop in pressure.
If the patient's blood alcohol level is over 125 mg/100 ml and the victim is not given timely help, then even death is possible.
How to combine
Some drugs should definitely not be combined with ethyl alcohol in any dose:
- nitroimidazoles;
- group of cephalosporins;
- fluoroquinolones;
- aminoglycosides.
How many days after antibiotics can you drink alcoholic beverages?Is it possible to interrupt the course of treatment for a while?
It is best not to combine antibiotics and alcohol at all and not to take ethanol during treatment.If for some reason this is not possible and you have to drink alcohol, then you can calculate how long after drinking an antibiotic you can use a special alcohol calculator.
The alcohol calculator takes into account the person's weight, the amount and strength of the drink taken.Thus, in men weighing 70 kg, 100 g of vodka will be completely eliminated from the body in 5.8 hours, and 200 g of beer - in 1.44 hours.
It should be borne in mind that all these calculations are approximate and the actual rate of elimination from the body depends not only on the properties of these chemical compounds, but also on the condition of the kidneys, intestines and liver.
Conclusion
For the complete removal of the antibacterial drug from the body, it should take from 1 to 3.5 - 5 days.Elimination time depends on a person's health, age and metabolic characteristics.
In most cases, drinking alcohol during a course of antibiotics weakens the effectiveness of the treatment, increases the side effects of the drug, provokes a disulfiram-like reaction and is fraught with serious consequences.